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Neuropathological Findings in the Very Old: Results from the First 101 Brains of a Population‐based Longitudinal Study of Dementing Disorders

Identifieur interne : 00BF67 ( Main/Exploration ); précédent : 00BF66; suivant : 00BF68

Neuropathological Findings in the Very Old: Results from the First 101 Brains of a Population‐based Longitudinal Study of Dementing Disorders

Auteurs : J. H. Xuereb [Royaume-Uni] ; C. Brayne [Royaume-Uni] ; C. Dufouil [France] ; H. Gertz [Allemagne] ; C. Wischik [Royaume-Uni] ; C. Harrington [Royaume-Uni] ; E. Mukaetova-Ladinska [Royaume-Uni] ; M. A. Mcgee [Royaume-Uni] ; A. O'Sullivan [Royaume-Uni] ; D. O'Connor [Australie] ; E. S. Paykel [Royaume-Uni] ; F. A. Huppert [Royaume-Uni]

Source :

Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2000-04.

RBID : ISTEX:7B580F4B73945C7A9292EA57413F1EDAF4BBB687

Descripteurs français

Wicri :
- topic : Santé publique.

English descriptors

Abstract

Abstract: We report a unique longitudinal epidemiological study of cognitive decline in the elderly population of the city of Cambridge, UK. A population sample of people aged 75 and over was surveyed between 1984–1996 (n= 2,616) and followed 2.4, 6, and 9 years later. CAMDEX diagnostic criteria were used for clinical assessment, and the neuropathological protocol (in 101 cases) was based on the CERAD method, with additional features to allow Braak staging of neurofibrillary pathology. The main findings are of the heterogeneity of lesions to be found in very old populations, and the existence of considerable overlap in the pathologies found in the demented and nondemented. It seems that white matter (ischemic) pallor an amyloid angiopathy, as well as neuritic plaques, neurofibrillary tangles and Lewy body formation are all lesions that increase the likelihood of dementia.

Url:

https://api.istex.fr/document/7B580F4B73945C7A9292EA57413F1EDAF4BBB687/fulltext/pdf

DOI: 10.1111/j.1749-6632.2000.tb06404.x

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amyloid</term>
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<term>Cognitive decline</term>
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<term>Clinicopathological studies</term>
<term>Cognitive decline</term>
<term>Considerable overlap</term>
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<term>Dementia expression</term>
<term>Dementia status</term>
<term>Diagnostic assessment</term>
<term>Epidemiological study</term>
<term>Extreme deafness</term>
<term>Lesion</term>
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<term>Lewy bodies</term>
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<front><div type="abstract">Abstract: We report a unique longitudinal epidemiological study of cognitive decline in the elderly population of the city of Cambridge, UK. A population sample of people aged 75 and over was surveyed between 1984–1996 (n= 2,616) and followed 2.4, 6, and 9 years later. CAMDEX diagnostic criteria were used for clinical assessment, and the neuropathological protocol (in 101 cases) was based on the CERAD method, with additional features to allow Braak staging of neurofibrillary pathology. The main findings are of the heterogeneity of lesions to be found in very old populations, and the existence of considerable overlap in the pathologies found in the demented and nondemented. It seems that white matter (ischemic) pallor an amyloid angiopathy, as well as neuritic plaques, neurofibrillary tangles and Lewy body formation are all lesions that increase the likelihood of dementia.</div>
</front>
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<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
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<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Xuereb, J H" sort="Xuereb, J H" uniqKey="Xuereb J" first="J. H." last="Xuereb">J. H. Xuereb</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Dufouil, C" sort="Dufouil, C" uniqKey="Dufouil C" first="C." last="Dufouil">C. Dufouil</name>
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<country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Gertz, H" sort="Gertz, H" uniqKey="Gertz H" first="H." last="Gertz">H. Gertz</name>
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<country name="Australie"><region name="Victoria (État)"><name sortKey="O Connor, D" sort="O Connor, D" uniqKey="O Connor D" first="D." last="O'Connor">D. O'Connor</name>
</region>
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</tree>
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Neuropathological Findings in the Very Old: Results from the First 101 Brains of a Population‐based Longitudinal Study of Dementing Disorders

Neuropathological Findings in the Very Old: Results from the First 101 Brains of a Population‐based Longitudinal Study of Dementing Disorders

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri